Publications

Apps for people with vision impairment: an international review of practitioner suggestions and app availability

Vijaya K Gothwal, Andrew Miller, Mei Ying Boon, Ahalya Subramanian, Alexis Malkin, Ava K Bittner

Clinical and Experimental Optometry · 2026

Refining How We Diagnose and Classify Limbal Stem Cell deficiency

Clemence Bonnet, Allan Slomovic, Friedrich Kruse, Sophie X. Deng

American Journal of Ophthalmology · 2026

DGAT1-associated lipid-retinoid dysregulation correlates with metabolic impairment in the RPE of Stargardt disease

Arpita Dave, Eunice Sze Yin Ng, Zhichun Jiang, Jane Hu, Jordan Tatang, Antonio Paniagua, Jeffrey Doeve, Sachin Parikh, Kevin J. Williams, Linsey Stiles, Roxana A. Radu

iScience · 2026

REPLY

Deyu Sun, Victoria L. Tseng, Fei Yu, Anne L. Coleman

Ophthalmology · 2026

Ocular Response Analyzer versus Goldmann Applanation Tonometry in a Population-based Sample: The Thessaloniki Eye Study

Rodanthi Christina Bartzoulianou, Anne L. Coleman, M. Roy Wilson, Alon Harris, Dimitrios A. Giannoulis, Georgios Bontzos, Anna-Bettina Haidich, Fei Yu, Vassileios Kilintzis, Iordanis Vagiakis, Eleftherios Anastasopoulos, Dimitrios Mikropoulos, Anastasia Raptou, Grigoria Tzoanou, Fotis Topouzis

American Journal of Ophthalmology · 2026

Outcomes of Descemet Stripping Endothelial Keratoplasty in Eyes With Anterior Chamber Intraocular Lenses

Reza Ghaffari, Alan W. Kong, Huong N. V. Duong, Sophie X. Deng, Anthony J. Aldave

Cornea · 2026

Evidence That Cardiac Pulse Strains Retinal Vessels in and near the Optic Disc During Ocular Ductions

Emanuil Parunakian, Atharva Shetye, Veronika Yehezkeli, Somaye Jafari, Joseph L. Demer

Bioengineering · 2026

E122Q rhodopsin: pigment microspectrophotometry, photoreceptor light responses, and bleaching adaptation

Christopher J. Meredith, Annabelle N. Tran, Alapakkam P. Sampath, Gordon L. Fain, Rikard Frederiksen

Journal of Comparative Physiology A · 2026

Dishevelled PDZ domain targeting peptides modulate non-canonical Wnt5a/Ror signaling

Andrew C. Jubintoro, Ho-Jin Lee, Hsin-Yi Henry Ho, Jie J. Zheng

Biochemistry and Biophysics Reports · 2026

Dual Knockout Models of the Spatially and Functionally Conserved rgra and rgrb Zebrafish Genes Reveal the Requirement of RGR for the Integrity of Cone‐Mediated Photopic Vision, the Photopic Visual Cycle and Bruch's Membrane Morphology

Grace Ruddin, Tess McCann, Joanna J. Kaylor, Michelle M. Fox, John D. Fehilly, Rebecca Ward, Adam Faulkner, Ailís L. Moran, Kieran Wynne, Roxana A. Radu, Michael G. Monaghan, Stephen D. Thorpe, Gabriel H. Travis, Breandán N. Kennedy

The FASEB Journal · 2026

Challenge to the concept of surgical dose-response for moderate to large angle exotropia

Soh Youn Suh, Qingyu Meng, Ami Tamhaney, Joseph L. Demer

Japanese Journal of Ophthalmology · 2026

Delayed Onset Infectious Crystalline Keratopathy After Corneal Cross-linking

Angela C. Chen, Sophie X. Deng, Anthony J. Aldave

Cornea · 2026

Strabismus Increases Glaucoma Risk in California Medicare Beneficiaries

Martin Ramirez, Ying Zheng, Victoria L. Tseng, Fei Yu, Joseph L. Demer, Anne L. Coleman

American Journal of Ophthalmology · 2026

Systemic and Metabolic Profile of Sagging Eye Syndrome: A Comparative Analysis

Veronika Yehezkeli, Janice J. Kim, Federico G. Velez, Joseph L. Demer, Stacy L. Pineles

American Journal of Ophthalmology · 2026

Projection targeting with phototagging to study the structure and function of retinal ganglion cells.

Bohlen MO, Rudzite AM, Daw TB, Kuczewski GM, Spiro E, Hammond C, Rogers DR, Gallego-Ortega A, Manookin MB, Roy S, Ritola K, Sommer MA, Field GD

Cell reports methods · 2026

Convergence Insufficiency After Bilateral Medial Rectus Recession for Age-Related Distance Esotropia?

Qingyu Meng, Veronika Yehezkeli, Emanuil Parunakian, Joseph L. Demer

American Journal of Ophthalmology · 2026

Retinal ganglion cell function: ON and OFF pathways.

Field GD

Handbook of clinical neurology · 2026

Limbal Epithelial Cells Detected in Stage III Limbal Stem Cell Deficiency by Multimodal Anterior Segment Imaging

AMERICAN JOURNAL OF OPHTHALMOLOGY · 2026

Surgical Dosing for V-Pattern Exotropia

Veronika Yehezkeli, Emanuil Parunakian, Soh Youn Suh, Qingyu Meng, Joseph L. Demer

American Journal of Ophthalmology · 2025

Surgical Dosing for Correction of Consecutive Exotropia

Qingyu Meng, Emanuil Parunakian, Veronika Yehezkeli, Joseph L. Demer

American Journal of Ophthalmology · 2025

Conservation of cis-regulatory codes over half a billion years of evolution

Gordon Fain, Ala Morshedian, Joseph C. Corbo, Yu Liu, Connie Myers, Yohey Ogawa, Alapakkam Sampath

Science Advances · 2025

A broadly neutralizing antibody confers cross-genus protection against alphaherpesviruses by inhibiting gB-mediated membrane fusion

Guosong Wang, Yu Li, Chongxin Wu, Tian Chen, Mengxuan Gui, Yue Zeng, Hui Sun, Kaiyun Chen, Xiangfeng Xi, Yanbo Yang, Yuchen Jiang, Yanan Jiang, Liqin Liu, Chengyu Yang, Jiarui Xin, Caihong Liu, Yiyi Li, Ningning Huo, Yang Huang, Lina Lin, Hai Yu, Chenghao Huang, Quan Yuan, Shaowei Li, Kegong Tian, Qingbing Zheng, Ningshao Xia, Yixin Chen

Nature Communications · 2025

Dysregulated DNA Methylation in Abca4-/- Retinal Pigment Epithelium: Insights into Early Stage of Stargardt Disease

Arpita Dave, Anela Tosevska, Marco Morselli, Emily Tom, Matteo Pellegrini, Dorota Skowronska-Krawczyk, Roxana A. Radu

International Journal of Molecular Sciences · 2025

Evolution of rod bipolar cells and rod vision

Rikard Frederiksen, Yi‐Rong Peng, Alapakkam P. Sampath, Gordon L. Fain

The Journal of Physiology · 2025

Outcome of Cenegermin in the Treatment of Neurotrophic Keratopathy

Golshan Latifi, Piseth Dalin Chea, Saba Al-Hashimi, Seyed Reza Ghaffari, Anthony J. Aldave, Sophie X. Deng, Simon S. M. Fung

Cornea · 2025

The Associations Between Glaucoma and Circadian Rhythm Sleep Disorders in California Medicare Beneficiaries

Martin Ramirez, Ken Kitayama, Allan Puran, Victoria L. Tseng, Fei Yu, Anne L. Coleman

American Journal of Ophthalmology · 2025

Demographics, Prevalence, and Characteristics of Limbal Stem Cell Deficiency in Southern California

Clemence Bonnet, Qihua Le, Daniel Cordova, Sheyla Gonzalez, Chi-Hong Tseng, Sophie X. Deng

Cornea · 2025

Predictors of Post-treatment Visual Improvement After Bacterial Keratitis Infection at a Referral Center in Southern California

Onyinye Onyia, Elise L. Ma, Kishan Gupta, Omai B. Garner, Sophie X. Deng, Simon S. M. Fung

Cornea · 2025

Retinal Ganglion Cell Diversity in Disease: Clinical Implications and Type-Specific Evaluation.

Makam R, Rider AT, Yu-Wai-Man P, Gilhooley MJ

Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society · 2025

Reasoning Large Language Model Errors Arise from Hallucinating Critical Problem Features

Alex Heyman

2025Preprint

Delayed Onset Infectious Crystalline Keratopathy After Corneal Cross-linking

Angela C. Chen, Sophie X. Deng, Anthony J. Aldave

Cornea · 2025

Photoreceptor degeneration induces homeostatic rewiring of rod bipolar cells

Paul J. Bonezzi, Rikard Frederiksen, Annabelle N. Tran, Kyle Kim, Gordon L. Fain, Alapakkam P. Sampath

Current Biology · 2025

Socioeconomic Status Mediates and Modifies Racial and Ethnic Disparities in Incisional Glaucoma Surgical Outcomes

Ken Kitayama, Yusuke Tsugawa, Akihiro Nishi, Anne L. Coleman

American Journal of Ophthalmology · 2025

Germline Disruption of Retinal Pigment Epithelium-Expressed Zebrafish rlbp1b-/- Results in Selective Dim Light Visual Behavior Deficits and Provides a Screening Platform for Evaluating the Pathogenicity of Human RLBP1 Variants

John Denis Fehilly, Tess McCann, Grace Ruddin, Joanna J. Kaylor, Hannah Grenville, Rebecca Ward, Kieran Wynne, Alicia Gómez Sánchez, Elin Strachan, Gabriel Travis, Ross F. Collery, Breandan Kennedy

The FASEB Journal · 2025

Common Forms of Adult Esotropia Require Augmented Surgical Dosing

Veronika Yehezkeli, Joseph L. Demer

American Journal of Ophthalmology · 2025

Finite Element Model of the Effect of Optic Nerve Sheath Anisotropy on Ocular Loading During Horizontal Duction

Somaye Jafari, Shengqiang Cai, Joseph L. Demer

Bioengineering · 2025

Surgical Management of Masquerading Superior Oblique Palsy

Qingyu Meng, Veronika Yehezkeli, Joseph L. Demer

American Journal of Ophthalmology · 2025

The Role of the Ca2+-activated Cl− Conductance in the Membrane Potential and Light Response of Mouse Rods

Rikard Frederiksen, Paul J. Bonezzi, Gordon L. Fain, Alapakkam P. Sampath

The Journal of Neuroscience · 2025

The dark and bright sides of retinal G protein-coupled receptor (RGR) in vision and disease

Grace Ruddin, Tess McCann, John D. Fehilly, Jodie Kearney, Breandán N. Kennedy

Progress in Retinal and Eye Research · 2025

Strabismus Surgery in Patients Aged Over 80 Years: Indications, Safety, and Outcomes

VERONIKA YEHEZKELI, STACY L. PINELES, JOSEPH L. DEMER, QINGYU MENG, FEDERICO G. VELEZ

American Journal of Ophthalmology · 2025

Advances in the Diagnosis and Management of Limbal Stem Cell Deficiency

Thanachaporn Kittipibul, Chea Piseth Dalin, Ali Masoudi, Jie Zheng, Sophie X. Deng

Cornea · 2025

Author Correction: Biophysical neural adaptation mechanisms enable artificial neural networks to capture dynamic retinal computation

Saad Idrees, Michael B. Manookin, Fred Rieke, Greg D. Field, Joel Zylberberg

Nature Communications · 2025

Collaborative role of two distinct cilium-specific cytoskeletal systems in driving Hedgehog-responsive transcription factor trafficking

David S. Williams, Radhika Subramanian, Pei-I Ku, Jamuna S Sreeja, Abhishek Chadha, Martin F Engelke

Science Advances · 2025

Temporal Transformation of the Rod Single-Photon Response in the Retinal Circuitry.

Okawa H, Sampath AP

Investigative ophthalmology & visual science · 2025

Laterality Targeting in Graded Inferior Rectus Tenotomy Corrects Lateral Incomitance of Hypertropia in Sagging Eye Syndrome

Wei-Yu Lai, Joseph L. Demer

American Journal of Ophthalmology · 2025

Cutaneous Lower Eyelid Retractor Release Averts Lower Lid Malposition After Inferior Rectus Muscle Recession

WEI-YU LAI, JOSEPH L. DEMER

American Journal of Ophthalmology · 2025

A single residue switch mediates the broad neutralization of Rotaviruses

Yang Huang, Feibo Song, Yuanjun Zeng, Hui Sun, Roufang Sheng, Xuechun Wang, Liqin Liu, Guoxing Luo, Yanan Jiang, Yaling Chen, Mengxuan Zhang, Shiyin Zhang, Ying Gu, Hai Yu, Shaowei Li, Tingdong Li, Qingbing Zheng, Shengxiang Ge, Jun Zhang, Ningshao Xia

Nature Communications · 2025

Derivation and Characterization of Isogenic OPA1 Mutant and Control Human Pluripotent Stem Cell Lines

Katherine A. Pohl, Xiangmei Zhang, Johnny Jeonghyun Ji, Linsey Stiles, Alfredo A. Sadun, Xian-Jie Yang

Cells · 2025

Microbiology Profiles and Antibiotic Susceptibility in Pediatric Microbial Keratitis

CORNEA · 2025

Visible Light OCT for Evaluating Palisades of Vogt

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · 2025

Presence of limbal epithelial cells in eyes with clinical Stage III limbal stem cell deficiency

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · 2025

Epithelial Layer Segmentation of Anterior Segment Optical Coherence Tomography in Eyes with Limbal Stem Cell Deficiency

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · 2025

Automated Segmentation of Central Corneal Basal Cells from In Vivo Confocal Microscopy Imaging

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · 2025

Comparison of Automated and Manual Measurement of Corneal Epithelial Thickness in Eyes With Limbal Stem Cell Deficiency

CORNEA · 2025

On the Feasibility of SERS-Based Monitoring of Drug Loading Efficiency in Exosomes for Targeted Delivery

BIOSENSORS-BASEL · 2025

Corneal Stromal Stem Cell-Derived Extracellular Vesicles Attenuate ANGPTL7 Expression in the Human Trabecular Meshwork

TRANSLATIONAL VISION SCIENCE & TECHNOLOGY · 2025

Finding Shared Decodable Concepts and their Negations in the Brain

Cory Daniel Efird, Alex Murphy, Joel Zylberberg, Alona Fyshe

The Thirteenth International Conference on Learning Representations · 2025Conference Paper

Tensile properties of glaucomatous human sclera, optic nerve, and optic nerve sheath

Joseph Park, Immi Lee, Somaye Jafari, Joseph L. Demer

Biomechanics and Modeling in Mechanobiology · 2024

Interaction between native and prosthetic visual responses in optogenetic visual restoration

Eleonora Carpentiero, Steven Hughes, Jessica Rodgers, Nermina Xhaferri, Sumit Biswas, Michael J Gilhooley, Mark W Hankins, Moritz Lindner

2024Preprint

Molecular characterization of the sea lamprey retina illuminates the evolutionary origin of retinal cell types

Junqiang Wang, Lin Zhang, Martina Cavallini, Ali Pahlevan, Junwei Sun, Ala Morshedian, Gordon L. Fain, Alapakkam P. Sampath, Yi-Rong Peng

Nature Communications · 2024

Structural insight into broadening SARS-CoV-2 neutralization by an antibody cocktail harbouring both NTD and RBD potent antibodies

Wenling Jiang, Yanan Jiang, Hui Sun, Tingting Deng, Kunyu Yu, Qianjiao Fang, Huimin Ge, Miaoling Lan, Yanling Lin, Zhongyue Fang, Yali Zhang, Lizhi Zhou, Tingting Li, Hai Yu, Qingbing Zheng, Shaowei Li, Ningshao Xia, Ying Gu

Emerging Microbes & Infections · 2024

Functional diversity in the output of the primate retina

A. Kling, S. Cooler, M.B. Manookin, C. Rhoades, N. Brackbill, G. Field, F. Rieke, A. Sher, A. Litke, E.J. Chichilnisky

2024Preprint

A new mouse model for PRPH2 pattern dystrophy exhibits functional compensation prior and subsequent to retinal degeneration.

Cavanaugh BL, Milstein ML, Boucher RC, Tan SX, Hanna MW, Seidel A, Frederiksen R, Saunders TL, Sampath AP, Mitton KP, Zhang DQ, Goldberg AFX

Human molecular genetics · 2024

Fine Granularity Is Critical for Intelligent Neural Network Pruning

Alex Heyman, Joel Zylberberg

Neural Computation · 2024

Functional organization and natural scene responses across mouse visual cortical areas revealed with encoding manifolds

Luciano Dyballa, Greg D. Field, Michael P. Stryker, Steven W. Zucker

2024Preprint

Should I stay or should I go? Generalized marginal value theorem with temporal discounting

Joel Zylberberg

2024Preprint

Biomechanics Explains Variability of Response of Small Hypertropia to Graded Vertical Rectus Tenotomy

Chang Zoo Kim, Seongjin Lim, Joseph L. Demer

American Journal of Ophthalmology · 2024

Biophysical neural adaptation mechanisms enable artificial neural networks to capture dynamic retinal computation

Saad Idrees, Michael B. Manookin, Fred Rieke, Greg D. Field, Joel Zylberberg

Nature Communications · 2024

Mutant mice with rod-specific VPS35 deletion exhibit retinal α-synuclein pathology-associated degeneration

Cheng Fu, Nan Yang, Jen-Zen Chuang, Nobuyuki Nakajima, Satoshi Iraha, Neeta Roy, Zhenquan Wu, Zhichun Jiang, Wataru Otsu, Roxana A. Radu, Howard Hua Yang, Maxwell Ping Lee, Tilla S. Worgall, Wen-Cheng Xiong, Ching-Hwa Sung

Nature Communications · 2024

RDH12 allows cone photoreceptors to regenerate opsin visual pigments from a chromophore precursor to escape competition with rods.

Kaylor JJ, Frederiksen R, Bedrosian CK, Huang M, Stennis-Weatherspoon D, Huynh T, Ngan T, Mulamreddy V, Sampath AP, Fain GL, Travis GH

Current biology : CB · 2024

Stimulus type shapes the topology of cellular functional networks in mouse visual cortex

Disheng Tang, Joel Zylberberg, Xiaoxuan Jia, Hannah Choi

Nature Communications · 2024

Conditional deletion of miR-204 and miR-211 in murine retinal pigment epithelium results in retinal degeneration

Samuel W. Du, Ravikiran Komirisetty, Dominik Lewandowski, Elliot H. Choi, Damian Panas, Susie Suh, Marcin Tabaka, Roxana A. Radu, Krzysztof Palczewski

Journal of Biological Chemistry · 2024

Impaired cathepsin D in retinal pigment epithelium cells mediates Stargardt disease pathogenesis

Eunice Sze Yin Ng, Jane Hu, Zhichun Jiang, Roxana A. Radu

The FASEB Journal · 2024

Postmortem Digital Image Correlation and Finite Element Modeling Demonstrate Posterior Scleral Deformations during Optic Nerve Adduction Tethering

Seongjin Lim, Changzoo Kim, Somaye Jafari, Joseph Park, Stephanie S. Garcia, Joseph L. Demer

Bioengineering · 2024

Genetic manipulation of rod-cone differences in mouse retina

Ala Morshedian, Zhichun Jiang, Roxana A. Radu, Gordon L. Fain, Alapakkam P. Sampath

PLOS ONE · 2024

Machine learning-based 3D segmentation of mitochondria in polarized epithelial cells

Nan W. Hultgren, Tianli Zhou, David S. Williams

Mitochondrion · 2024

Finite element model of ocular adduction with unconstrained globe translation

Somaye Jafari, Joseph Park, Yongtao Lu, Joseph L. Demer

Biomechanics and Modeling in Mechanobiology · 2024

Local synaptic inhibition mediates cerebellar granule cell pattern separation and enables learned sensorimotor associations

Elizabeth A. Fleming, Greg D. Field, Michael R. Tadross, Court Hull

Nature Neuroscience · 2024

Evolutionary and developmental specialization of foveal cell types in the marmoset

Lin Zhang, Martina Cavallini, Junqiang Wang, Ruiqi Xin, Qiangge Zhang, Guoping Feng, Joshua R. Sanes, Yi-Rong Peng

Proceedings of the National Academy of Sciences · 2024

GABAergic Inhibition Controls Receptive Field Size, Sensitivity, and Contrast Preference of Direction Selective Retinal Ganglion Cells Near the Threshold of Vision

Suva Roy, Xiaoyang Yao, Jay Rathinavelu, Greg D. Field

The Journal of Neuroscience · 2024

Keratitis Fugax Hereditaria Associated With a Novel NLRP3 Mutation in a Non-Finnish Patient

Kavya Jatavallabhula, Onyinye Onyia, Doug D. Chung, Dominic Williams, Kaidi Wang, Anthony J. Aldave

Cornea · 2024

Magnetic Resonance Imaging of Globe Translation in Abducens Palsy

Changzoo Kim, Joseph L. Demer

American Journal of Ophthalmology · 2024

Two antibodies show broad, synergistic neutralization against SARS-CoV-2 variants by inducing conformational change within the RBD

Hui Sun, Tingting Deng, Yali Zhang, Yanling Lin, Yanan Jiang, Yichao Jiang, Yang Huang, Shuo Song, Lingyan Cui, Tingting Li, Hualong Xiong, Miaolin Lan, Liqin Liu, Yu Li, Qianjiao Fang, Kunyu Yu, Wenling Jiang, Lizhi Zhou, Yuqiong Que, Tianying Zhang, Quan Yuan, Tong Cheng, Zheng Zhang, Hai Yu, Jun Zhang, Wenxin Luo, Shaowei Li, Qingbing Zheng, Ying Gu, Ningshao Xia

Protein & Cell · 2024

Somatic Mutations within Myocilin due to Aging May Be a Potential Risk Factor for Glaucoma

Yevgeniy Sazhnyev, Akaash Venkat, Jie J. Zheng

Genes · 2024

Investigation of the functional impact of CHED- and FECD4-associated SLC4A11 mutations in human corneal endothelial cells

Doug D. Chung, Angela C. Chen, Charlene H. Choo, Wenlin Zhang, Dominic Williams, Christopher G. Griffis, Paul Bonezzi, Kavya Jatavallabhula, Alapakkam P. Sampath, Anthony J. Aldave

PLOS ONE · 2024

Inherited Optic Neuropathies: Real-World Experience in the Paediatric Neuro-Ophthalmology Clinic

Michael James Gilhooley, Naz Raoof, Patrick Yu-Wai-Man, Mariya Moosajee

Genes · 2024

Responses to Pattern-Violating Visual Stimuli Evolve Differently Over Days in Somata and Distal Apical Dendrites

Colleen J. Gillon, Jason E. Pina, Jérôme A. Lecoq, Ruweida Ahmed, Yazan N. Billeh, Shiella Caldejon, Peter Groblewski, Timothy M. Henley, India Kato, Eric Lee, Jennifer Luviano, Kyla Mace, Chelsea Nayan, Thuyanh V. Nguyen, Kat North, Jed Perkins, Sam Seid, Matthew T. Valley, Ali Williford, Yoshua Bengio, Timothy P. Lillicrap, Blake A. Richards, Joel Zylberberg

The Journal of Neuroscience · 2024

Positive cooperativity in synergistic activation of Wnt proteins

MOLECULAR BIOLOGY REPORTS · 2024

Three-Dimensional Reconstruction of Subbasal Nerve Density in Eyes With Limbal Stem Cell Deficiency: A Pilot Study

CORNEA · 2024

Co-existence of Neurotrophic Keratopathy in Eyes With Limbal Stem Cell Deficiency

AMERICAN JOURNAL OF OPHTHALMOLOGY · 2024

Limbal stem cell therapy

CURRENT OPINION IN OPHTHALMOLOGY · 2024

High-Throughput Quantification of Corneal Fibrosis after Treatment with Extracellular Vesicles from Human Corneal Stromal Stem Cells

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · 2024

Structural and functional changes of corneal innervation after treatment with cenegermin

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · 2024

Corneal stromal stem cell -derived extracellular vesicles attenuate ANGPTL7 expression in human trabecular meshwork.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · 2024

Deep Learning Model for Segmenting the Epithelial Layer in Anterior Segment Optical Coherence Tomography

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · 2024

Adapting Cellpose for Segmentation and Quantification of Cultivated Limbal Stem Cells

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · 2024

Late gene therapy limits the restoration of retinal function in a mouse model of retinitis pigmentosa

Miranda L. Scalabrino, Mishek Thapa, Tian Wang, Alapakkam P. Sampath, Jeannie Chen, Greg D. Field

Nature Communications · 2023

OPA1 Dominant Optic Atrophy: Pathogenesis and Therapeutic Targets

David C. S. Wong, Joshua P. Harvey, Neringa Jurkute, Sara M. Thomasy, Mariya Moosajee, Patrick Yu-Wai-Man, Michael J. Gilhooley

Journal of Neuro-Ophthalmology · 2023

Evolutionary and Developmental Specialization of Foveal Cell Types in the Marmoset

Lin Zhang, Martina Cavallini, Junqiang Wang, Ruiqi Xin, Qiangge Zhang, Guoping Feng, Joshua R. Sanes, Yi-Rong Peng

2023Preprint

Towards automated sleep-stage classification for adaptive deep brain stimulation targeting sleep in patients with Parkinson’s disease

Katrina Carver, Karin Saltoun, Elijah Christensen, Aviva Abosch, Joel Zylberberg, John A. Thompson

Communications Engineering · 2023

Structural basis for broad neutralization of human antibody against Omicron sublineages and evasion by XBB variant

Hui Sun, Yizhen Wang, Xiuting Chen, Yanan Jiang, Siling Wang, Yang Huang, Liqin Liu, Yu Li, Miaolin Lan, Huilin Guo, Quan Yuan, Yali Zhang, Tingting Li, Hai Yu, Ying Gu, Jun Zhang, Shaowei Li, Zizheng Zheng, Qingbing Zheng, Ningshao Xia

Journal of Virology · 2023

Scanning Laser Ophthalmoscopy Demonstrates Disc and Peripapillary Strain During Horizontal Eye Rotation in Adults

Joseph Park, Sunghyuk Moon, Seongjin Lim, Joseph L. Demer

American Journal of Ophthalmology · 2023

Empirical Quantification of Optic Nerve Strain Due to Horizontal Duction

Seongjin Lim, Joseph L. Demer

Bioengineering · 2023

Cell-type specification in the retina: Recent discoveries from transcriptomic approaches

Yi-Rong Peng

Current Opinion in Neurobiology · 2023

Fungal Infection After Descemet Membrane Endothelial Keratoplasty: Incidence and Outcomes

Brittany M. Wong, Clémence Bonnet, Reza Ghaffari, Kourtney Houser, Jennifer DeMatteo, Nicola Lau, Anthony J. Aldave

Cornea · 2023

Population encoding of stimulus features along the visual hierarchy

Luciano Dyballa, Andra M. Rudzite, Mahmood S. Hoseini, Mishek Thapa, Michael P. Stryker, Greg D. Field, Steven W. Zucker

2023Preprint

Biophysical neural adaptation mechanisms enable artificial neural networks to capture dynamic retinal computation

Saad Idrees, Michael B. Manookin, Fred Rieke, Greg D. Field, Joel Zylberberg

2023Preprint

Light Adaptation of Retinal Rod Bipolar Cells

Khris G. Griffis, Katherine E. Fehlhaber, Fred Rieke, Alapakkam P. Sampath

The Journal of Neuroscience · 2023

Prospective, Randomized, Multicenter, Double-Masked, Clinical Trial of Corneal Cross-Linking for Boston Keratoprosthesis Carrier Tissue

Sofia De Arrigunaga, Esen K. Akpek, Anthony J. Aldave, Shahzad I. Mian, David Zurakowski, Joseph B. Ciolino

American Journal of Ophthalmology · 2023

Dexamethasone Modulates the Dynamics of Wnt Signaling in Human Trabecular Meshwork Cells

Chi Zhang, Elizabeth Tannous, Alseena Thomas, Natalia Jung, Edmond Ma, Jie J. Zheng

Vision · 2023

Responses of pyramidal cell somata and apical dendrites in mouse visual cortex over multiple days

Colleen J. Gillon, Jérôme A. Lecoq, Jason E. Pina, Ruweida Ahmed, Yazan N. Billeh, Shiella Caldejon, Peter Groblewski, Timothy M. Henley, India Kato, Eric Lee, Jennifer Luviano, Kyla Mace, Chelsea Nayan, Thuyanh V. Nguyen, Kat North, Jed Perkins, Sam Seid, Matthew T. Valley, Ali Williford, Yoshua Bengio, Timothy P. Lillicrap, Joel Zylberberg, Blake A. Richards

Scientific Data · 2023

Novel DCN Mutation in Armenian Family With Congenital Stromal Corneal Dystrophy

Dominic Williams, Doug D. Chung, Anna Hovakimyan, Araks Davtyan, Ben J. Glasgow, Anthony J. Aldave

Cornea · 2023

Reply to Comment on: Masquerading superior oblique palsy

Joseph l. Demer, Robert A. Clark

American Journal of Ophthalmology · 2023

Single mRNA detection of Wnt signaling pathway in the human limbus

Clémence Bonnet, Maxime Ruiz, Sheyla Gonzalez, Chi-Hong Tseng, Jean-Louis Bourges, Francine Behar-Cohen, Sophie X. Deng

Experimental Eye Research · 2023

Late gene therapy limits the restoration of retinal function in a mouse model of retinitis pigmentosa

Miranda L. Scalabrino, Mishek Thapa, Tian Wang, Alapakkam P. Sampath, Jeannie Chen, Greg D. Field

2023Preprint

Cones and cone pathways remain functional in advanced retinal degeneration

Erika M. Ellis, Antonio E. Paniagua, Miranda L. Scalabrino, Mishek Thapa, Jay Rathinavelu, Yuekan Jiao, David S. Williams, Greg D. Field, Gordon L. Fain, Alapakkam P. Sampath

Current Biology · 2023

A Novel Role for UNC119 as an Enhancer of Synaptic Transmission

Katherine E. Fehlhaber, Anurima Majumder, Kimberly K. Boyd, Khris G. Griffis, Nikolai O. Artemyev, Gordon L. Fain, Alapakkam P. Sampath

International Journal of Molecular Sciences · 2023

Infectious Crystalline Keratopathy Secondary to Mycobacterium chelonae

Clémence Bonnet, Alex C. Onishi, Anthony J. Aldave

Cornea · 2023

Encoding of environmental illumination by primate melanopsin neurons

Andreas Liu, Elliott S. Milner, Yi-Rong Peng, Hannah A. Blume, Michael C. Brown, Gregory S. Bryman, Alan J. Emanuel, Philippe Morquette, Nguyen-Minh Viet, Joshua R. Sanes, Paul D. Gamlin, Michael Tri H. Do

Science · 2023

Latent diffusion augmentation enhances deep learning analysis of neuro-morphology in limbal stem cell deficiency

FRONTIERS IN MEDICINE · 2023

Wnt activation as a potential therapeutic approach to treat partial limbal stem cell deficiency

SCIENTIFIC REPORTS · 2023

Ocular Surface Regeneration by Limbal Stem Cells Therapies: State of the Art, Challenges, and Perspectives

STEM CELLS TRANSLATIONAL MEDICINE · 2023

Corneal sensation and subbasal nerve density are reduced in eyes with limbal stem cell deficiency.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · 2023

Comparison of automated and manual measurements of corneal epithelial thickness in eyes with limbal stem cell deficiency

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · 2023

A Wnt mimic as a therapeutic approach to treat partial limbal stem cell deficiency: an in vitro model using single human limbal stem/progenitor cells

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · 2023

Exosomes for the treatment of corneal disorders

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · 2023

An Automated Deep Learning Approach for the Diagnosis of Limbal Stem Cell Deficiency

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · 2023

Future regenerative therapies for corneal disease

CURRENT OPINION IN OPHTHALMOLOGY · 2023

Submillimeter-Wave Cornea Phantom Sensing Over an Extended Depth of Field With an Axicon-Generated Bessel Beam

IEEE TRANSACTIONS ON TERAHERTZ SCIENCE AND TECHNOLOGY · 2023

Clinical outcomes and complications of fluid-filled scleral lens devices for the management of limbal stem cell deficiency

CONTACT LENS & ANTERIOR EYE · 2023

Descemet membrane endothelial keratoplasty in eyes with glaucoma

TAIWAN JOURNAL OF OPHTHALMOLOGY · 2023

Autologous Serum Eye Drops in the Management of Limbal Stem Cell Deficiency Associated With Glaucoma Surgery

EYE & CONTACT LENS-SCIENCE AND CLINICAL PRACTICE · 2023

Membrane Attack Complex Mediates Retinal Pigment Epithelium Cell Death in Stargardt Macular Degeneration

Eunice Ng, Nermin Kady, Jane Hu, Arpita Dave, Zhichun Jiang, Jacqueline Pei, Michael Gorin, Anna Matynia, Roxana Radu

Cells · 2022

Masquerading Superior Oblique Palsy

Joseph L. Demer, Robert A. Clark

American Journal of Ophthalmology · 2022

Cones and Cone Pathways Remain Functional in Advanced Retinal Degeneration

Erika M. Ellis, Antonio E. Paniagua, Miranda L. Scalabrino, Mishek Thapa, Jay Rathinavelu, Yuekan Jiao, David S. Williams, Greg D. Field, Gordon L. Fain, Alapakkam P. Sampath

2022Preprint

Large scale interrogation of retinal cell functions by 1-photon light-sheet microscopy

Suva Roy, Depeng Wang, Andra M. Rudzite, Benjamin Perry, Miranda L. Scalabrino, Mishek Thapa, Yiyang Gong, Alexander Sher, Greg D. Field

2022Preprint

Efficient coding, channel capacity and the emergence of retinal mosaics

Na Young Jun, Greg D. Field, John M. Pearson

2022Preprint

Robust cone-mediated signaling persists late into rod photoreceptor degeneration

Miranda L Scalabrino, Mishek Thapa, Lindsey A Chew, Esther Zhang, Jason Xu, Alapakkam P Sampath, Jeannie Chen, Greg D Field

eLife · 2022

R-etodolac is a more potent Wnt signaling inhibitor than enantiomer, S-etodolac

JoAnn S. Roberts, Chao Ma, Sarah Y.T. Robertson, Stephen Kang, Christiana S. Han, Sophie X. Deng, Jie J. Zheng

Biochemistry and Biophysics Reports · 2022

Dawn and dusk peaks of outer segment phagocytosis, and visual cycle function require Rab28

Ailís L. Moran, Stephen P. Carter, Joanna J. Kaylor, Zhichun Jiang, Sanne Broekman, Eugene T. Dillon, Alicia Gómez Sánchez, Sajal K. Minhas, Erwin van Wijk, Roxana A. Radu, Gabriel H. Travis, Michelle Carey, Oliver E. Blacque, Breandán N. Kennedy

The FASEB Journal · 2022

Robust cone-mediated signaling persists late into rod photoreceptor degeneration

Miranda L. Scalabrino, Mishek Thapa, Lindsey A. Chew, Esther Zhang, Jason Xu, A.P. Sampath, Jeannie Chen, Greg D. Field

2022Preprint

A hyperpolarizing rod bipolar cell in the sea lamprey, Petromyzon marinus

Rikard Frederiksen, Gordon L. Fain, Alapakkam P. Sampath

Journal of Experimental Biology · 2022

Premise and peril of Wnt signaling activation through GSK-3β inhibition

Samuel M. Law, Jie J. Zheng

iScience · 2022

Applying Protein–Protein Interactions and Complex Networks to Identify Novel Genes in Retinitis Pigmentosa Pathogenesis

Su-Bin Yoon, Yu Chien Ma, Akaash Venkat, Chun Yu Liu, Jie J. Zheng

International Journal of Molecular Sciences · 2022

A systematic comparison of optogenetic approaches to visual restoration.

Gilhooley MJ, Lindner M, Palumaa T, Hughes S, Peirson SN, Hankins MW

Molecular therapy. Methods & clinical development · 2022

Characterizing the metabolic profile of dexamethasone treated human trabecular meshwork cells

Kimberly Graybeal, Luis Sanchez, Chi Zhang, Linsey Stiles, Jie J. Zheng

Experimental Eye Research · 2022

Generation of Functional Immortalized Human Corneal Stromal Stem Cells

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES · 2022

Infectious Keratitis Isolates and Susceptibility in Southern California

CORNEA · 2022

Cell Morphology as an In Vivo Parameter for the Diagnosis of Limbal Stem Cell Deficiency

CORNEA · 2022

Cytokeratin 13 Is a New Biomarker for the Diagnosis of Limbal Stem Cell Deficiency

CORNEA · 2022

Comment on: Long-Term Outcome After Superficial Keratectomy of the Abnormal Epithelium for Partial Limbal Stem Cell Deficiency

AMERICAN JOURNAL OF OPHTHALMOLOGY · 2022

Non-canonical Wnt signaling via Wnt16b improves human limbal epithelial stem/progenitor cell maintenance

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · 2022

Developing Scalable Purification of Small Extracellular Vesicles Using Size Exclusion Chromatography

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · 2022

Anti-Inflammatory and Anti-Fibrotic Activities of Human Corneal Stromal Stem Cells and Their Extracellular Vesicles Measured by in vitro Assays

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · 2022

Extracellular miR-6723-5p could serve as a biomarker of limbal epithelial stem/progenitor cell population

BIOMARKER RESEARCH · 2022

650 GHz Imaging as Alignment Verification for Millimeter Wave Corneal Reflectometry

IEEE TRANSACTIONS ON TERAHERTZ SCIENCE AND TECHNOLOGY · 2022

R-etodolac is a more potent Wnt signaling inhibitor than enantiomer, S-etodolac

BIOCHEMISTRY AND BIOPHYSICS REPORTS · 2022

MobileNetV2 Based Diagnosis and Grading of Limbal Stem Cell Deficiency

2022 IEEE 22ND INTERNATIONAL CONFERENCE ON BIOINFORMATICS AND BIOENGINEERING (BIBE 2022) · 2022

Biomarkers of in vivo limbal stem cell function

OCULAR SURFACE · 2022

Stability and Function of Extracellular Vesicles Derived from Immortalized Human Corneal Stromal Stem Cells: A Proof of Concept Study

AAPS JOURNAL · 2022

Wnt Signalosome Assembly by Small Molecule Wnt-Mimic

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · 2022

Wnt signaling pathway in the human limbus: a comprehensive mapping by single mRNA detection

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · 2022

Rapid 3D bioprinting of a multicellular model recapitulating pterygium microenvironment

BIOMATERIALS · 2022

Reproducibility of the Rod Photoreceptor Response Depends Critically on the Concentration of the Phosphodiesterase Effector Enzyme

Journal of Neuroscience · 2022

Assessing Variant Causality and Severity Using Retinal Pigment Epithelial Cells Derived from Stargardt Disease Patients

Translational Vision Science and Technology · 2022

Lipofuscin causes atypical necroptosis through lysosomal membrane permeabilization

Chendong Pan, Kalpita Banerjee, Guillermo L. Lehmann, Dena Almeida, Katherine A. Hajjar, Ignacio Benedicto, Zhichun Jiang, Roxana A. Radu, David H. Thompson, Enrique Rodriguez-Boulan, Marcelo M. Nociari

Proceedings of the National Academy of Sciences · 2021

Age at Glaucoma Diagnosis in Germline Myocilin Mutation Patients: Associations with Polymorphisms in Protein Stabilities

Tarin Tanji, Emily Cohen, Darrick Shen, Chi Zhang, Fei Yu, Anne L. Coleman, Jie J. Zheng

Genes · 2021

Bluetooth Low Energy Beacon Sensors to Document Handheld Magnifier Use at Home by People with Low Vision

Ava K. Bittner, Max Estabrook, Niki Dennis

Sensors · 2021

Scene statistics and noise determine the relative arrangement of receptive field mosaics

Na Young Jun, Greg D. Field, John Pearson

Proceedings of the National Academy of Sciences · 2021

Light responses of mammalian cones

Gordon L. Fain, Alapakkam P. Sampath

Pflügers Archiv - European Journal of Physiology · 2021

Material properties and effect of preconditioning of human sclera, optic nerve, and optic nerve sheath

Joseph Park, Andrew Shin, Somaye Jafari, Joseph L. Demer

Biomechanics and Modeling in Mechanobiology · 2021

Good decisions require more than information

N. Alex Cayco-Gajic, Joel Zylberberg

Nature Neuroscience · 2021

“Genetic and clinical findings in an ethnically diverse retinitis pigmentosa cohort associated with pathogenic variants in EYS”

Olivia Cundy, Suzanne Broadgate, Stephanie Halford, Robert E. MacLaren, Morag E. Shanks, Penny Clouston, Michael J. Gilhooley, Susan M. Downes

Eye · 2021

Inter-mosaic coordination of retinal receptive fields

Suva Roy, Na Young Jun, Emily L. Davis, John Pearson, Greg D. Field

Nature · 2021

Rod Photoreceptors Avoid Saturation in Bright Light by the Movement of the G Protein Transducin

Rikard Frederiksen, Ala Morshedian, Sonia A. Tripathy, Tongzhou Xu, Gabriel H. Travis, Gordon L. Fain, Alapakkam P. Sampath

The Journal of Neuroscience · 2021

Properties of multivesicular release from mouse rod photoreceptors support transmission of single-photon responses

Cassandra L Hays, Asia L Sladek, Greg D Field, Wallace B Thoreson

eLife · 2021

The optimal spatial arrangement of ON and OFF receptive fields

Na Young Jun, Greg Field, John Pearson

2021Preprint

Strabismus After Ahmed Glaucoma Valve Implantation

Laura Robbins, Toshiaki Goseki, Simon K. Law, Kouros Nouri-Mahdavi, Joseph Caprioli, Anne L. Coleman, Joann A. Giaconi, Joseph L. Demer, Federico G. Velez, Stacy L. Pineles

American Journal of Ophthalmology · 2021

Properties of multi-vesicular release from rod photoreceptors support transmission of single photon responses

CL Hays, AL Sladek, GD Field, WB Thoreson

2021Preprint

The functional characteristics of optogenetic gene therapy for vision restoration

Moritz Lindner, Michael J. Gilhooley, Stuart N. Peirson, Steven Hughes, Mark W. Hankins

Cellular and Molecular Life Sciences · 2021

Functional Anatomy of Muscle Mechanisms: Compensating Vertical Heterophoria

Joseph L. Demer, Robert A. Clark

American Journal of Ophthalmology · 2021

Reply to: Comment on Prevalence of Sagging Eye Syndrome in Adults with Binocular Diplopia

Toshiaki Goseki, Soh Youn Suh, Laura Robbins, Stacy L. Pineles, Joseph L. Demer, Federico G. Velez

American Journal of Ophthalmology · 2021

From Transcriptomics to Treatment in Inherited Optic Neuropathies

Michael James Gilhooley, Nicholas Owen, Mariya Moosajee, Patrick Yu Wai Man

Genes · 2021

ON-bipolar cell gene expression during retinal degeneration: Implications for optogenetic visual restoration.

Experimental eye research · 2021

Human limbal epithelial stem cell regulation, bioengineering and function

PROGRESS IN RETINAL AND EYE RESEARCH · 2021

Regulation of Limbal Epithelial Stem Cells: Importance of the Niche

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES · 2021

Extraction of Thickness and Water-Content Gradients in Hydrogel-Based Water-Backed Corneal Phantoms Via Submillimeter-Wave Reflectometry

IEEE TRANSACTIONS ON TERAHERTZ SCIENCE AND TECHNOLOGY · 2021

Wnt6 plays a complex role in maintaining human limbal stem/progenitor cells

SCIENTIFIC REPORTS · 2021

Sutured Custom Foldable Silicone Artificial Iris Implantation Combined With Intraocular Lens Implantation and Penetrating Keratoplasty: Safety and Efficacy Outcomes

CORNEA · 2021

Bioprinting of dual ECM scaffolds encapsulating limbal stem/progenitor cells in active and quiescent statuses

BIOFABRICATION · 2021

Submillimeter-Wave Permittivity Measurements of Bound Water in Collagen Hydrogels via Frequency Domain Spectroscopy

IEEE TRANSACTIONS ON TERAHERTZ SCIENCE AND TECHNOLOGY · 2021

Wnt signaling activation: targets and therapeutic opportunities for stem cell therapy and regenerative medicine

RSC CHEMICAL BIOLOGY · 2021

Limbal stem cell diseases

EXPERIMENTAL EYE RESEARCH · 2021

THz frequency, Goniometric scanning system for human cornea using off-axis parabolic mirrors

2021 46TH INTERNATIONAL CONFERENCE ON INFRARED, MILLIMETER AND TERAHERTZ WAVES (IRMMW-THZ) · 2021

Automatic Estimation of Limbal Stem Cell Densities in Cultured Epithelial Cell Microscopy Imaging

2021 IEEE 21ST INTERNATIONAL CONFERENCE ON BIOINFORMATICS AND BIOENGINEERING (IEEE BIBE 2021) · 2021

Investigation of optimal THz band for corneal water content quantification

2021 CONFERENCE ON LASERS AND ELECTRO-OPTICS EUROPE & EUROPEAN QUANTUM ELECTRONICS CONFERENCE (CLEO/EUROPE-EQEC) · 2021