Edmund Tsui Laboratory
Uveitis and Ocular Inflammatory Diseases
Advancing the diagnosis and treatment of uveitis through cutting-edge imaging technologies and clinical trials
Edmund Tsui, M.D., M.S.
Associate Professor
Department of Ophthalmology
Jules Stein Eye Institute
The Tsui Research Group is committed to advancing the field of uveitis through innovative imaging analysis, improved diagnostic tools, and clinical trials. By leveraging advanced imaging modalities such as optical coherence tomography, we aim to quantify objectively intraocular inflammation and enhance diagnostic accuracy in uveitis. Our work also includes developing standardized methodologies for assessing inflammation, and conducting clinical trials to evaluate novel therapeutics in the treatment of uveitis and ocular inflammatory disease.
Our research focuses on these areas:
- Image Analysis: Develop and validate imaging biomarkers using optical coherence tomography (OCT) and other advanced imaging modalities to quantify intraocular inflammation and monitor disease activity in uveitis. This work aims to improve the objectivity of diagnostic assessments, enhance disease monitoring, and guide treatment decisions by leveraging cutting-edge imaging technologies.
- Advanced Diagnostics: Utilize ocular fluid sampling techniques, such as aqueous and vitreous humor analysis, to improve the diagnosis of uveitis. This includes cytokine profiling, pathogen detection, and biomarker discovery to enable precision diagnostics and uncover underlying etiologies of ocular inflammation.
- Clinical Trials: Design and conduct clinical trials to evaluate novel therapies and refine treatment strategies for uveitis and other ocular inflammatory diseases. Our research encompasses immune-modulating therapies, biologics, small molecules, and targeted immunotherapies aimed at reducing inflammation, preventing vision loss, and improving patient outcomes.
These research areas reflect our group’s mission to advance the understanding, diagnosis, and treatment of uveitis and ocular inflammatory diseases through innovation and collaboration.
Recent Publications
Suprachoroidal Triamcinolone Acetonide for the Management of Retinal Vasculitis
Marcus Yamamoto, Justin Hanson, Marko Popovic, Cherilyn Palochak, Kirk Hou, Colin McCannel, Judy L. Chen, Irena Tsui, Edmund Tsui
OCULAR IMMUNOLOGY AND INFLAMMATION (2026)
View PublicationAngular Sign of Henle Fiber Layer Hyperreflectivity (ASHH) in Cancer-Associated Retinopathy
Alessandro Feo, Marko M. Popovic, Edmund Tsui
OCULAR IMMUNOLOGY AND INFLAMMATION (2026)
View PublicationPediatric Uveitic Macular Edema in Noninfectious Uveitis <i>Structural and Visual Outcomes and Predictors of Visual Prognosis</i>
Alessandro Feo, Shani Pillar, Paolo Forte, Alberto Quarta, Justin S. Yun, Anamika Patel, Marko M. Popovic, Kelly K. Tran, Edmund Tsui
OPHTHALMOLOGY RETINA (2026)
View PublicationQuantitative Analysis of Retinal Fluid by a Deep Learning Model in Uveitic Macular Edema
Anthony Wu, Adrian Au, Justin Hanson, Marcus Yamamoto, Joy Cheng, Simon Lee, Tal Eshkoly Lior, Oren Avram, SriniVas R. Sadda, Alison B. Coyne, Nisha R. Acharya, Brian Madow, Jeffrey N. Chiang, Edmund Tsui
OPHTHALMOLOGY SCIENCE (2026)
View PublicationMirvetuximab Soravtansine Exposure and Incidence of Cataract Surgery
Jordyn F. Silverstein, Alexandra Smick, Edmund Tsui, Oladunni Alomaja, Bridget Johnson, Chi-Hong Tseng, Ritu Salani, Dennis J. Slamon, Dana M. Chase, Gottfried E. Konecny
JAMA NETWORK OPEN (2026)
View PublicationIntraretinal hyperreflective foci: Pathophysiology, imaging features, and clinical implications across retinal diseases
Giacomo Boscia, Alessandro Feo, Alberto Quarta, Elisa Stradiotto, Paolo Forte, Alba Chiara Termite, Rodolfo Mastropasqua, Alfonso Savastano, Michele Reibaldi, Chiara Maria Eandi, Francesco Boscia, Maria Vittoria Cicinelli, Adrian Au, Edmund Tsui, Stela Vujosevic, Ursula Schmidt-Erfurth, David Sarraf, SriniVas R. Sadda, Mario R. Romano, Enrico Borrelli, Pasquale Viggiano
PROGRESS IN RETINAL AND EYE RESEARCH (2026)
View PublicationAnterior segment optical coherence tomography in uveitis: A comprehensive review of clinical applications, diagnostic insights, and future directions
Alessandro Feo, Prashant D. Tailor, Adrian Au, Anthony Wu, Ali Haidar, Mario R. Romano, SriniVas R. Sadda, Edmund Tsui
SURVEY OF OPHTHALMOLOGY (2026)
View PublicationExpanded Spectrum of Chrysanthemum and Miliary Multifocal Choroiditis With Panuveitis: Novel Imaging and Pathophysiological Insights
Alessandro Feo, Alberto Quarta, Prithvi Ramtohul, Demi Miller, Kareem Moussa, Eric Crowell, K. Bailey Freund, Edmund Tsui
AMERICAN JOURNAL OF OPHTHALMOLOGY (2026)
View PublicationImaging Measures for the Assessment of Disease Activity in Noninfectious Posterior Uveitis-Multimodal Imaging in Uveitis (MUV) Taskforce: Report 10
ANIRUDDHA AGARWAL, PRITHVI RAMTOHUL, ALESSANDRO INVERNIZZI, SAPNA GANGAPUTRA, EDMUND TSUI, ANNABELLE A. OKADA, JENNIFER E. THORNE, MARC D. DE SMET, BAHRAM BODAGHI, CARLOS PAVESIO, DOUGLAS A. JABS, SRINIVAS SADDA, DAVID SARRAF, VISHALI GUPTA, Alejandra de-la-Torre, Alejandro Fonollosa, Alessandro Invernizzi, Amani Fawzi, Andrew Dick, Aniruddha Agarwal, Anita Agarwal, Antoine Brezin, Ariel Schlaen, Bahram Bodaghi, Claudia Fabiani, David Sarraf, Debra A. Goldstein, Dilraj Grewal, Douglas A. Jabs, Edmund Tsui, Elisabetta Miserocchi, Ester Carreño, Francesco Pichi, Ilknur Tugal-Tutkun, Inês Leal, Janet L. Davis, Jeannette Ossewaarde-van Norel, Jennifer E. Thorne, Jessica G. Shantha, Jose S. Pulido, Justine R. Smith, Jyotirmay Biswas, K. Bailey Freund, Kathryn Pepple, Lee M. Jampol, Luca Cimino, Marc De Smet, Maria Vittoria Cicinelli, Marion R. Munk, Massimo Accorinti, Maura Di Nicola, Meghan Berkenstock, Michael Altaweel, Phoebe Lin, Quan Dong Nguyen, Richard Spaide, Rupesh Agrawal, Sapna S. Gangaputra, Soon Phaik Chee, SriniVas Sadda, Sumit Sharma, Timothy M. Janetos, Vishali Gupta, Zohar Habot-Wilner
AMERICAN JOURNAL OF OPHTHALMOLOGY (2026)
View PublicationForecasting the Workforce of Uveitis Specialists
ANIKA SHAH, SEAN T. BERKOWITZ, EDMUND TSUI, JOHN A. GONZALES, ERIC L. CROWELL, SAPNA GANGAPUTRA
AMERICAN JOURNAL OF OPHTHALMOLOGY (2026)
View Publication