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Ben Glasgow Laboratory

Ophthalmic Pathology and Tear Film Biochemistry

Investigating the molecular mechanisms underlying tear film stability and ocular surface health

Dr. Ben Glasgow

Ben J. Glasgow, M.D.

Professor

The Wasserman Professor of Ophthalmology

Departments of Pathology and Laboratory Medicine and Ophthalmology

Jules Stein Eye Institute

bglasgow@mednet.ucla.eduFaculty Profile

The Glasgow laboratory focuses on understanding the molecular mechanisms that regulate tear film stability and their implications for ocular surface disorders. His research explores the structure and function of tear lipocalins and their interactions with lipids to maintain ocular health.

Key research questions include:

  • What are the structural mechanisms by which tear lipocalins stabilize the tear film?
  • How do lipid-protein interactions contribute to ocular surface health?
  • What roles do tear film components play in protecting against environmental stressors?
  • How can insights into tear film biochemistry inform treatments for dry eye syndrome?
  • What are the molecular pathways involved in lipid layer dysfunction in ocular diseases?

Dr. Glasgow's work integrates biochemistry, structural biology, and clinical studies to advance our understanding of the tear film's role in maintaining a healthy ocular surface. His findings have significant implications for developing therapies for dry eye syndrome and other related conditions.

Selected Publications

Tear lipocalin: Structure, function, and molecular mechanisms

Glasgow BJ, Gasymov OK

Progress in Retinal and Eye Research (2020) • 85 citations

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Lipid binding properties of tear lipocalins and their role in the ocular surface

Gasymov OK, Abduragimov AR, Glasgow BJ

Investigative Ophthalmology & Visual Science (2018) • 72 citations

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Structural basis for tear film lipid layer stability by tear lipocalin interactions with phospholipids

Glasgow BJ, Gasymov OK, Abduragimov AR

Journal of Biological Chemistry (2016) • 65 citations

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Pathophysiology of ocular surface disorders and the role of tear lipocalins

Glasgow BJ, Gasymov OK

Experimental Eye Research (2014) • 59 citations

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