Gilhooley Laboratory

Research in our lab centers on the intrinsically photosensitive retinal ganglion cells of the optic nerve (ipRGCs) and the fascinating protein that renders them sensitive to light (melanopsin). We are particularly interested in defining the mechanisms by which ipRGCs survive in optic nerve disease, in some cases long after vision is lost as more conventional types of retinal ganglion cell die.

This survival is particularly notable in the inherited optic neuropathies — Leber Hereditary Optic Neuropathy (LHON) and Dominant Optic Atrophy (DOA), caused by mutations in genes central to mitochondrial function (such as OPA1 in DOA). Uncovering why ipRGCs are so resilient to mitochondrial dysfunction in these eye diseases is essential not only to develop novel treatments to protect sight, but potentially in more common forms of neurodegeneration where mitochondrial dysfunction is implicated.

Dr. Gilhooley combines his clinical expertise in inherited optic neuropathies with basic science investigation to translate findings from ipRGC biology toward neuroprotective therapies for patients.