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Aya Barzalay-Wollman Laboratory

Robotic Microsurgery and Retinal Regeneration

Dr. Aya Barzalay-Wollman

Aya Barzelay-Wollman, M.D., Ph.D.

Assistant Professor

Department of Ophthalmology

Jules Stein Eye Institute

ayaba@g.ucla.edu
Faculty Profile
Website

Dr. Aya Barzelay-Wollman leads a translational research program focused on advancing robotic-assisted microsurgery for retinal disease. Her lab develops AI-guided robotic systems capable of performing delicate intraocular surgeries with sub-millimeter precision—enabling tasks such as retinal vein cannulation, targeted subretinal delivery of gene and drug therapies, and automated intravitreal injections that exceed human manual capabilities.

Her research also explores regenerative strategies using stem cell–derived retinal grafts to replace damaged retinal tissue in degenerative diseases like age-related macular degeneration. By combining microsurgical robotics with cell-based therapies, her team aims to improve the precision, consistency, and long-term integration of these treatments, accelerating their translation into clinical care.

Dr. Barzelay-Wollman is the UCLA principal investigator for a national ARPA-H–funded initiative on whole eye transplantation. Her contributions focus on robotic microsurgery and intraocular tissue preservation, developing enabling technologies to support the viability and functional integration of transplanted eyes.

Surgical Robot

Selected Publications

Revolutionizing Vitreo-Retinal Surgery: Unveiling Advanced Robotic Surgery and Intraocular Imaging Innovations

Barzelay-Wollman, A.

EURETINA Annual Meeting, Barcelona, Spain (2024)

Add-On Fluidic Control System for Enhancing Intraocular Pressure Stabilization and Reducing Tissue Deformation

Barzelay-Wollman, A., Lai, Y.T.

IEEE/ASME International Conference on Advanced Intelligent Mechatronics (AIM) (2024)

Sequential Fabrication of a Three-Layer Retina-like Structure

Shechter, Y., Cohen, R., Namestnikov, M., Shapira, A., Barak, A., Barzelay-Wollman, A., Dvir, T.

Gels (2024)

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Regenerative Effect of Adipose-Derived Mesenchymal Stem Cells on Ganglion Cells in the Hypoxic Organotypic Retina Culture

Dov, M.B., Krief, B., Benhamou, M., Klein, A., Schwartz, S., Loewenstein, A., Barak, A., Barzelay-Wollman, A.

International Journal of Stem Cells (2023)

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Retinal Lineage Therapeutic Specific Effect of Human Orbital and Abdominal Adipose-Derived Mesenchymal Stem Cells

Krief, B., Algor, S.W., Nakdimon, I., Elhikis, A., Benhamou, M., Kadmon, A.S., Keren, S., Ohana, O., Feldman, I., Cnaan, R., Leibovitch, I., Loewenstein, A., Barak, A., Barzelay-Wollman, A.

Stem Cells International (2021)

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