




Aya Barzelay-Wollman Laboratory
Robotic Microsurgery and Retinal Regeneration

Aya Barzelay-Wollman, M.D., Ph.D.
Assistant Professor
Department of Ophthalmology
Jules Stein Eye Institute
ayaba@g.ucla.eduFaculty Profile
Website
Dr. Aya Barzelay-Wollman leads a translational research program focused on advancing robotic-assisted microsurgery for retinal disease. Her lab develops AI-guided robotic systems capable of performing delicate intraocular surgeries with sub-millimeter precision—enabling tasks such as retinal vein cannulation, targeted subretinal delivery of gene and drug therapies, and automated intravitreal injections that exceed human manual capabilities.
Her research also explores regenerative strategies using stem cell–derived retinal grafts to replace damaged retinal tissue in degenerative diseases like age-related macular degeneration. By combining microsurgical robotics with cell-based therapies, her team aims to improve the precision, consistency, and long-term integration of these treatments, accelerating their translation into clinical care.
Dr. Barzelay-Wollman is the UCLA principal investigator for a national ARPA-H–funded initiative on whole eye transplantation. Her contributions focus on robotic microsurgery and intraocular tissue preservation, developing enabling technologies to support the viability and functional integration of transplanted eyes.

Selected Publications
Revolutionizing Vitreo-Retinal Surgery: Unveiling Advanced Robotic Surgery and Intraocular Imaging Innovations
Barzelay-Wollman, A.
EURETINA Annual Meeting, Barcelona, Spain (2024)
Add-On Fluidic Control System for Enhancing Intraocular Pressure Stabilization and Reducing Tissue Deformation
Barzelay-Wollman, A., Lai, Y.T.
IEEE/ASME International Conference on Advanced Intelligent Mechatronics (AIM) (2024)
Sequential Fabrication of a Three-Layer Retina-like Structure
Shechter, Y., Cohen, R., Namestnikov, M., Shapira, A., Barak, A., Barzelay-Wollman, A., Dvir, T.
Gels (2024)
View PublicationRegenerative Effect of Adipose-Derived Mesenchymal Stem Cells on Ganglion Cells in the Hypoxic Organotypic Retina Culture
Dov, M.B., Krief, B., Benhamou, M., Klein, A., Schwartz, S., Loewenstein, A., Barak, A., Barzelay-Wollman, A.
International Journal of Stem Cells (2023)
View PublicationRetinal Lineage Therapeutic Specific Effect of Human Orbital and Abdominal Adipose-Derived Mesenchymal Stem Cells
Krief, B., Algor, S.W., Nakdimon, I., Elhikis, A., Benhamou, M., Kadmon, A.S., Keren, S., Ohana, O., Feldman, I., Cnaan, R., Leibovitch, I., Loewenstein, A., Barak, A., Barzelay-Wollman, A.
Stem Cells International (2021)
View Publication